Vemurafenib is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.
Our Vemurafenib API and Intermediates is as following,we have all the below API and intermedites offering all year.
Vemurafenib cas 84832-02-0,Vemurafenib Cas 1103234-56-5,Vemurafenib Cas 183208-35-7,
Vemurafenib Cas 918516-27-5,Vemurafenib Cas 1392273-41-4,Vemurafenib Cas 1029872-54-5
Vemurafenib Cas 1103234-56-5,Vemurafenib Cas 183208-35-7,Vemurafenib Cas 918516-27-5,Vemurafenib Cas 84832-02-0 Â Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com
Company Profile
Quality is our culture
A trustworthy partner
In-saiL is dedicated to manufacturing of precision components and the design, fabrication of engineering specialty fasteners and fastening solution development.
Manufacturing Capability
We have powerful manufacturing capability, our automatic lathes, CNC lathes, CNC machining centers, stamping machines and cold heading machines plus auxiliary equipment like milling machine, grinding machine, EDM and the cooperation of our partners, we are able to support every different components regardless of the prototyping or series production.
Automation Components
Available for a variety of sizes automation components,In-saiL provides solutions to suit any customer need.
Auto Lathe Turning
The single shaft cam-base automatic lathes are capable of massive production of brass, aluminum alloy, stainless steel components.
Production range: O.D. 0.5-15
CNC Milling
4-axis and 5-axis machining centers are capable of complex structural parts.
Production range: 800x600
Screw Heading & Rolling
The screw production lines finish the cold heading and thread rolling for small carbon steel or stainless steel screws.
Production range: M0.8-M6 or equivalent sized imperial screws
Stamping
Stamping machines perform the blanking, punching, blending, drawing. Currently we are working on simple stamping jobs.
Production range: 200T max.
Company Profile:
Quality is our culture
A trustworthy partner
In-saiL is dedicated to manufacturing of precision components and the design, fabrication of engineering specialty fasteners and fastening solution development.
Product Details:
Material:Steel 12L14
Surface Treatment:Green blue zinc
The salt spray test is reach up to 72 hours
Strict production control per as drawings
CE ROHS,ISO9001:2008
We have the following types of equipment:
1.Conventional and CNC Lathes and auto lathes
2.Conventional and CNC Milling Machines
3.High Speed CNC Machining Centres
4.4-axis CNC Machining Centres
5.Precision Wire Cut Machines
6.Surface and Cylindrical Grinders
We also perform various heat treatment processes and metal finishing, chrome, nickel plating and anodizing
Our advantage:
1. Experienced technical staff
2. Product warranty
3. Prompt delivery
4. Quality approval
5. Small order accepted.
6. Competitive price
7. First-class service
Packing method:
Can provide various sizes and packing according to specific requirements
Packing material: PP bag, copy paper, carton, wooden box, pallets
Meet export requirement
According to customer's required
We have many years of experience in the production of OEM, and we have developed products known for quality and service. Look forward to cooperating with you!
Â
Material
Aluminum alloy,Brass,Stainless Steel,Carbon steel,according to customer's requirement
Finish
Milled /Tin plating, copper-plating,hot-dip galvanizing, black oxide coating,red anodized,black anodized,painting,
powdering,rust preventive oil, titanium alloy galvanized, silver plating, plastic, electroplating, anodizing etc.
Testing Equipment
CMM,Projector,Pull Tester,Automatic Optic Inspector,Projecting apparatus
Salt Spray Test, Durometer, and Coating Analyzer,Tensile Machine
Management System
ISO9001:2008
Certification
SGS,RoHS,Material Certication,PPAP
Production Capability
Auto-lathe turning:ODΦ0.5-20mm,Tol.±0.01mm
CNC lathe turning:ODΦ0.5-250mm,Tol.±0.005mm CNC Milling:800x600mm(LxW),Tol.±0.05mm Grinding:Tol.±0.002mm Screw heading & rolling:Metric 0.8-M6,Unified Imperial#0-1/4'' Stamping:200T max
Lead Time
5-15 working days
Samples
Welcome
Delivery term
By DHL,UPS,TNT,FedEx,EMS,By Ocean,By Air
Warranty
Replacement at all our cost for rejected products
Company Profile
Quality is our culture
A trustworthy partner
In-saiL is dedicated to manufacturing of precision components and the design, fabrication of engineering specialty fasteners and fastening solution development.
Manufacturing Capability
We have powerful manufacturing capability, our automatic lathes, CNC lathes, CNC machining centers, stamping machines and cold heading machines plus auxiliary equipment like milling machine, grinding machine, EDM and the cooperation of our partners, we are able to support every different components regardless of the prototyping or series production.
Automation Components
Available for a variety of sizes automation components,In-saiL provides solutions to suit any customer need.
Auto Lathe Turning
The single shaft cam-base automatic lathes are capable of massive production of brass, aluminum alloy, stainless steel components.
Production range: O.D. 0.5-15
CNC Milling
4-axis and 5-axis machining centers are capable of complex structural parts.
Production range: 800x600
Screw Heading & Rolling
The screw production lines finish the cold heading and thread rolling for small carbon steel or stainless steel screws.
Production range: M0.8-M6 or equivalent sized imperial screws
Stamping
Stamping machines perform the blanking, punching, blending, drawing. Currently we are working on simple stamping jobs.
Production range: 200T max.
Company Profile:
Quality is our culture
A trustworthy partner
In-saiL is dedicated to manufacturing of precision components and the design, fabrication of engineering specialty fasteners and fastening solution development.
Product Details:
Material:Steel 12L14
Surface Treatment:Green blue zinc
The salt spray test is reach up to 72 hours
Strict production control per as drawings
CE ROHS,ISO9001:2008
We have the following types of equipment:
1.Conventional and CNC Lathes and auto lathes
2.Conventional and CNC Milling Machines
3.High Speed CNC Machining Centres
4.4-axis CNC Machining Centres
5.Precision Wire Cut Machines
6.Surface and Cylindrical Grinders
We also perform various heat treatment processes and metal finishing, chrome, nickel plating and anodizing
Our advantage:
1. Experienced technical staff
2. Product warranty
3. Prompt delivery
4. Quality approval
5. Small order accepted.
6. Competitive price
7. First-class service
Packing method:
Can provide various sizes and packing according to specific requirements
Packing material: PP bag, copy paper, carton, wooden box, pallets
Meet export requirement
According to customer's required
We have many years of experience in the production of OEM, and we have developed products known for quality and service. Look forward to cooperating with you!
Â
Material
Aluminum alloy,Brass,Stainless Steel,Carbon steel,according to customer's requirement
Finish
Milled /Tin plating, copper-plating,hot-dip galvanizing, black oxide coating,red anodized,black anodized,painting,
powdering,rust preventive oil, titanium alloy galvanized, silver plating, plastic, electroplating, anodizing etc.
Testing Equipment
CMM,Projector,Pull Tester,Automatic Optic Inspector,Projecting apparatus
Salt Spray Test, Durometer, and Coating Analyzer,Tensile Machine
Management System
ISO9001:2008
Certification
SGS,RoHS,Material Certication,PPAP
Production Capability
Auto-lathe turning:ODΦ0.5-20mm,Tol.±0.01mm
CNC lathe turning:ODΦ0.5-250mm,Tol.±0.005mm CNC Milling:800x600mm(LxW),Tol.±0.05mm Grinding:Tol.±0.002mm Screw heading & rolling:Metric 0.8-M6,Unified Imperial#0-1/4'' Stamping:200T max
Lead Time
5-15 working days
Samples
Welcome
Delivery term
By DHL,UPS,TNT,FedEx,EMS,By Ocean,By Air
Warranty
Replacement at all our cost for rejected products
DIN Stainless Steel Hex Socket Cap Head Assemblies Screws
Model NO.: DIN, AS, JIS, ISO, Inch, Metric
Grade: A2
Model No.: Machine Screw
Series: Hex Socket Cap Head Screws
Surface Treatment: Plain,Passivating,Black,Color-Zinc,Blue-White Zin
Design: OEM Services Provided
Application: Machinery,Chemical Industry,Environmental
Inspection: 100% QC Steps Inspect Before Shipment
Manufacture Processing: Cold Heading,Machining,Automatic Lathe
Export Markets: Global
Trademark: In-sail
Transport Package: PE Bag +Carton
Specification: CE
Origin: Shenzhen, Guangdong
HS Code: 7318140000
Model NO.: DIN, AS, JIS, ISO, Inch, Metric
Grade: A2
Model No.: Machine Screw
Series: Hex Socket Cap Head Screws
Surface Treatment: Plain,Passivating,Black,Color-Zinc,Blue-White Zin
Design: OEM Services Provided
Application: Machinery,Chemical Industry,Environmental
Inspection: 100% QC Steps Inspect Before Shipment
Manufacture Processing: Cold Heading,Machining,Automatic Lathe
Export Markets: Global
Trademark: In-sail
Transport Package: PE Bag +Carton
Specification: CE
Origin: Shenzhen, Guangdong
HS Code: 7318140000
DIN Stainless Steel Hex Socket Cap Head Assemblies Screws