Exploring the micro world has China's "eyes"

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According to the Science and Technology Daily, the National Major Scientific Research Equipment Development Project “Development of Super-Resolution Micro-Optics Core Components and Systems” undertaken by the Suzhou Medical Laboratories of the Chinese Academy of Sciences passed the acceptance on the 26th. This indicates that China has the ability to develop high-end super-resolution optical microscopes.

In today's biological and basic medical research, high/super-resolution optical microscopy plays an important role, and super-resolution micro-optical imaging at 10-100 nm scale is an important means to obtain original research results. Previously, China basically relied on imports, which seriously restricted innovation in China's related frontier areas.

After five years of research, the researchers at Suzhou Medical Institute have completely broken through key technologies such as large numerical aperture objective lens, special light source, new nano fluorescent enhancement reagent, system integration and detection; developed laser scanning confocal microscope, two-photon microscope, and stimulated High-end optical microscopes such as emission loss (STED) super-resolution microscope and two-photon-STED microscope; built high-end micro-optical processing, assembly, inspection and microscope integrated technology integration engineering platform for the development of high-end optical microscope in China A system solution is provided.

The super-resolution microscope and core components developed by Suzhou Medical Institute have been used by many research institutions at home and abroad and have achieved results. This animal used by the Chinese Academy of Sciences to observe the basic phenomena in developmental biology and study the potential regulatory mechanisms; the intracellular targeting and delivery of this observation drug used by the Chinese Academy of Sciences drugs accelerated the development of innovative new drugs. The Stanford University and the University of Tokyo in Japan used two-photon microscopy imaging technology to study the core issues of brain science such as information recognition and behavior control, as well as animal in vivo imaging experiments, and obtained high-resolution real-time neuron activity imaging data.

It is understood that the project team published 61 related papers, authorized 35 invention patents, authorized 56 utility model patents, and trained a super-resolution micro-optical technology in the fields of optics, mechanics, electronics, computers, software and materials. R&D and engineering development team.


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